Which two medications are commonly prescribed SSRIs, and what is a common side effect?

• A. Venlafaxine and Duloxetine; Hypertension
• B. Fluoxetine and Sertraline; Sexual dysfunction
• C. Haloperidol and Chlorpromazine; Extrapyramidal symptoms
• D. Amitriptyline and Nortriptyline; Anticholinergic effects

Answer: (B)

SSRIs are a common first-line class that increase serotonin signaling to help improve mood and anxiety symptoms. Fluoxetine and sertraline are classic examples of this class. A well-recognized side effect of SSRIs is sexual dysfunction, such as reduced libido, delayed orgasm, or anorgasmia, which can occur for many patients and may affect treatment adherence. The other options point to different drug classes or side effects: venlafaxine and duloxetine are SNRIs, with hypertension not being the defining hallmark; haloperidol and chlorpromazine are antipsychotics associated with extrapyramidal symptoms; amitriptyline and nortriptyline are TCAs with anticholinergic effects. Therefore, fluoxetine and sertraline together with sexual dysfunction best fits.