What is a common risk with benzodiazepine use and an important clinical consideration?

• A. Hypertension and tachycardia
• B. Sedation and dependence; risk of withdrawal and should be used short-term
• C. Hyperlipidemia and liver toxicity
• D. Sexual dysfunction

Answer: (B)

Benzodiazepines can cause CNS depression that leads to sedation and impaired coordination, which is why sedation is a common and clinically important effect. More crucially, they carry a real risk of physiological dependence, with withdrawal symptoms if the medication is reduced too quickly or stopped after ongoing use. Because of these issues, they are typically prescribed for short periods and with a careful taper plan rather than as long-term solutions. Clinically, use the lowest effective dose, monitor for increased sedation or falls—especially in older patients or when combined with alcohol or opioids—and prefer alternative treatments for longer-term management, such as SSRIs or psychotherapy, when appropriate.